USC-OGP 2-DE database Two-dimensional polyacrylamide gel electrophoresis database

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Searching in 'USC-OGP 2-DE database' for entry matching: P21281 USC-OGP 2-DE database:  P21281 P21281 General information about the entry View entry in simple text format Entry name VATB2_HUMAN Primary accession number P21281 integrated into USC-OGP 2-DE database on  January 17, 2017 (release 1) 2D Annotations were last modified on January 17, 2017 (version 1) General Annotations were last modified on  April 5, 2017 (version 2) Name and origin of the protein Description RecName: Full=V-type proton ATPase subunit B, brain isoform; Short=V-ATPase subunit B 2; AltName: Full=Endomembrane proton pump 58 kDa subunit; AltName: Full=HO57; AltName: Full=Vacuolar proton pump subunit B 2;. Gene name Name=ATP6V1B2 Synonyms=ATP6B2, VPP3 Annotated species Homo sapiens (Human) [TaxID: 9606] Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. References [1]   2D GEL CHARACTERIZATION Author 1., Author 2. Submitted (Mar-2011) to Current 2D PAGE maps for identified proteins How to interpret a protein UVEAL_MELANOMA_3-10 {UVEAL MELANOMA 3-10} Homo sapiens (Human)   map experimental info   UVEAL_MELANOMA_3-10 MAP LOCATIONS: SPOT OGP-1151: pI=5.63; Mw=55013 Cross-references UniProtKB/Swiss-Prot P21281; VATB2_HUMAN. 2D PAGE maps for identified proteins How to interpret a protein map You may obtain an estimated location of the protein on various 2D PAGE maps, provided the whole amino acid sequence is known. The estimation is obtained according to the computed protein's pI and Mw. Warning 1: the displayed region reflects an area around the theoretical pI and molecular weight of the protein and is only provided for the user's information. It should be used with caution, as the experimental and theoretical positions of a protein may differ significantly. Warning 2: the 2D PAGE map is built on demand. This may take some few seconds to be computed. External data extracted from UniProtKB/Swiss-Prot Extracted from UniProtKB/Swiss-Prot, release: 0.0 Entry name VATB2_HUMAN Primary accession number P21281 Secondary accession number(s) B2R5Z3 D3DSQ5 Q14544 Q15859 Q96IR0 Sequence was last modified on  December 1, 2000 (version 3) Annotations were last modified on  March 15, 2017 (version 182) Name and origin of the protein Description RecName: Full=V-type proton ATPase subunit B, brain isoform; Short=V-ATPase subunit B 2; AltName: Full=Endomembrane proton pump 58 kDa subunit; AltName: Full=HO57; AltName: Full=Vacuolar proton pump subunit B 2; Gene name Name=ATP6V1B2 Synonyms=ATP6B2, VPP3 Encoded on Name=ATP6V1B2; Synonyms=ATP6B2, VPP3 Keywords Complete proteome; Deafness; Disease mutation; Hydrogen ion transport; Hydrolase; Ion transport; Membrane; Reference proteome; Transport. Copyright Copyrighted by the UniProt Consortium, see http://www.uniprot.org/help/license. Distributed under the Creative Commons Attribution-NoDerivs License Cross-references EMBL M60346; AAA35610.1; -; mRNA EMBL L35249; AAA58661.1; -; mRNA EMBL AK312372; BAG35290.1; -; mRNA EMBL CH471080; EAW63758.1; -; Genomic_DNA EMBL CH471080; EAW63759.1; -; Genomic_DNA EMBL BC003100; AAH03100.1; -; mRNA EMBL BC007309; AAH07309.1; -; mRNA EMBL BC030640; AAH30640.1; -; mRNA EMBL Z37165; CAA85522.1; -; Genomic_DNA EMBL X62949; CAA44721.1; -; mRNA CCDS CCDS6014.1; -; . PIR B44138; B44138; . PIR I39208; I39208; . RefSeq NP_001684.2; NM_001693.3; . UniGene Hs.295917; -; . ProteinModelPortal P21281; -; . SMR P21281; -; . BioGrid 107009; 114; . DIP DIP-47433N; -; . IntAct P21281; 36; . MINT MINT-5004128; -; . STRING 9606.ENSP00000276390; -; . BindingDB P21281; -; . ChEMBL CHEMBL5641; -; . DrugBank DB07347; 4-(2-AMINOETHYL)BENZENESULFONYL FLUORIDE; . DrugBank DB05260; Gallium nitrate; . GuidetoPHARMACOLOGY 812; -; . TCDB 3.A.2.2.4; the h(+)- or na(+)-translocating f-type; v-type and a-type atpase (f-atpase) superfamily; . iPTMnet P21281; -; . PhosphoSitePlus P21281; -; . SwissPalm P21281; -; . BioMuta ATP6V1B2; -; . DMDM 12643271; -; . REPRODUCTION-2DPAGE IPI00007812; -; . EPD P21281; -; . MaxQB P21281; -; . PaxDb P21281; -; . PeptideAtlas P21281; -; . PRIDE P21281; -; . DNASU 526; -; . Ensembl ENST00000276390; ENSP00000276390; ENSG00000147416; . GeneID 526; -; . KEGG hsa:526; -; . UCSC uc003wzp.4; human; . CTD 526; -; . DisGeNET 526; -; . GeneCards ATP6V1B2; -; . HGNC HGNC:854; ATP6V1B2; . HPA HPA008147; -; . MalaCards ATP6V1B2; -; . MIM 124480; phenotype; . MIM 606939; gene; . MIM 616455; phenotype; . neXtProt NX_P21281; -; . OpenTargets ENSG00000147416; -; . Orphanet 79499; Autosomal dominant deafness-onychodystrophy syndrome; . PharmGKB PA25155; -; . eggNOG KOG1351; Eukaryota; . eggNOG COG1156; LUCA; . GeneTree ENSGT00550000074724; -; . HOGENOM HOG000165320; -; . HOVERGEN HBG002176; -; . InParanoid P21281; -; . KO K02147; -; . OMA WRERRYL; -; . OrthoDB EOG091G04TR; -; . PhylomeDB P21281; -; . TreeFam TF300313; -; . BioCyc MetaCyc:HS07429-MONOMER; -; . Reactome R-HSA-1222556; ROS; RNS production in phagocytes; . Reactome R-HSA-77387; Insulin receptor recycling; . Reactome R-HSA-917977; Transferrin endocytosis and recycling; . Reactome R-HSA-983712; Ion channel transport; . ChiTaRS ATP6V1B2; human; . GeneWiki ATP6V1B2; -; . GenomeRNAi 526; -; . PRO PR:P21281; -; . Proteomes UP000005640; Chromosome 8; . Bgee ENSG00000147416; -; . CleanEx HS_ATP6V1B2; -; . ExpressionAtlas P21281; baseline and differential; . Genevisible P21281; HS; . GO GO:0005829; C:cytosol; ISS:UniProtKB; . GO GO:0012505; C:endomembrane system; IEA:UniProtKB-SubCell; . GO GO:0070062; C:extracellular exosome; IDA:UniProtKB; . GO GO:0016021; C:integral component of membrane; IEA:Ensembl; . GO GO:0043231; C:intracellular membrane-bounded organelle; IDA:HPA; . GO GO:0005765; C:lysosomal membrane; IDA:UniProtKB; . GO GO:0042470; C:melanosome; IEA:UniProtKB-SubCell; . GO GO:0005902; C:microvillus; IEA:Ensembl; . GO GO:0043209; C:myelin sheath; IEA:Ensembl; . GO GO:0005886; C:plasma membrane; ISS:UniProtKB; . GO GO:0033180; C:proton-transporting V-type ATPase; V1 domain; IEA:InterPro GO GO:0001726; C:ruffle; IEA:Ensembl; . GO GO:0005524; F:ATP binding; IEA:InterPro; . GO GO:0015078; F:hydrogen ion transmembrane transporter activity; TAS:ProtInc; . GO GO:0046961; F:proton-transporting ATPase activity; rotational mechanism; TAS:ProtInc GO GO:0015991; P:ATP hydrolysis coupled proton transport; IEA:InterPro; . GO GO:0046034; P:ATP metabolic process; IEA:InterPro; . GO GO:0008286; P:insulin receptor signaling pathway; TAS:Reactome; . GO GO:0034220; P:ion transmembrane transport; TAS:Reactome; . GO GO:0090383; P:phagosome acidification; TAS:Reactome; . GO GO:0015992; P:proton transport; TAS:ProtInc; . GO GO:0016241; P:regulation of macroautophagy; NAS:ParkinsonsUK-UCL; . GO GO:0033572; P:transferrin transport; TAS:Reactome; . Gene3D 3.40.50.300; -; 1; . HAMAP MF_00310; ATP_synth_B_arch; 1; . InterPro IPR020003; ATPase_a/bsu_AS; . InterPro IPR004100; ATPase_F1/V1/A1_a/bsu_N; . InterPro IPR000194; ATPase_F1/V1/A1_a/bsu_nucl-bd; . InterPro IPR005723; ATPase_V1-cplx_bsu; . InterPro IPR027417; P-loop_NTPase; . InterPro IPR022879; V-ATPase_su_B/beta; . PANTHER PTHR43389; PTHR43389; 1; . Pfam PF00006; ATP-synt_ab; 1; . Pfam PF02874; ATP-synt_ab_N; 1; . PIRSF PIRSF039114; V-ATPsynth_beta/V-ATPase_B; 1; . SUPFAM SSF52540; SSF52540; 1; . TIGRFAMs TIGR01040; V-ATPase_V1_B; 1; . PROSITE PS00152; ATPASE_ALPHA_BETA; 1; .

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